The most famous paintings of all timeMona Lisa by Leonardo da Vinci (1503-1505) ... The Birth of Venus by Sandro Botticelli (1486) ... The Creation of Adam by Michelangelo Buonarroti (1511) ... The Last Supper by Leonardo da Vinci (1495—1498) ... Sacred and Profane Love by Tiziano Vecelli (1515—1516)