Long-Range Hunting Calibers for Big Game Animals6.5 Creedmoor. Despite the pessimists out there, the 6.5 Creedmoor has a lot going for it in terms of the best long-range hunting calibers. ... . 270 Winchester. ... 7mm Remington Magnum. While you don't see much of the 7mm Rem. ... . 308 Winchester. ... . 30-06 Springfield. ... .