Best Caliber for Deer Hunting7mm-08 Remington. ... 280 Remington. ... 7mm Remington Magnum. ... 30-30 Winchester. ... 308 Winchester. ... 30-06. ... 300 Winchester Magnum.You might be surprised by the number of hunters that use the 300 as their primary deer rifle. An exceptional round for long range, it gives no quarter in performance on whitetail.